Alpha synuclein in neurodegenerative disorders: Murderer or accomplice?
نویسندگان
چکیده
منابع مشابه
Interaction between α-Synuclein and Other Proteins in Neurodegenerative Disorders
Protein aggregation is a common characteristic of many neurodegenerative disorders, and the interaction between pathological/toxic proteins to cause neurodegeneration is a hot topic of current neuroscience research. Despite clinical, genetic, and experimental differences, evidence increasingly indicates considerable overlap between synucleinopathies and tauopathies or other protein-misfolding d...
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-Synuclein is an abundant presynaptic brain protein, misfolding, aggregation and fibrillation of which are implicated as critical factors in several neurodegenerative diseases. The list of the well-known synucleinopathies includes such devastating disorders as Parkinson’s disease, Lewy body variant of Alzheimer’s disease, diffuse Lewy body disease, dementia with Lewy bodies, multiple system atr...
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There is strong evidence for the involvement of alpha-synuclein in the pathologies of several neurodegenerative disorders, including PD (Parkinson's disease). Development of disease appears to be linked to processes that increase the rate at which alpha-synuclein forms aggregates. These processes include increased protein concentration (via either increased rate of synthesis or decreased rate o...
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Alzheimer's disease and Parkinson's disease are the most common neurodegenerative disorders of the human brain. They are characterized by the presence of ordered filamentous assemblies which gradually develop in a small number of nerve cell types. I n Alzheimer's disease, vulnerable nerve cells develop neurofibrillary tangles, neuropil threads and abnormal neurites, whereas in Parkinson's disea...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 1998
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm0798-755